2013年3月22日星期五

Different Types of Proteinuria

What is proteinuria?
Proteinuria is not always sick.It has two parts ,including functional proteinuria and pathological proteinuria.
Functional proteinuria which is also called physiological proteinuria, is that temporary proteinuria in healthy people. More common in young people ,as for the influence of strenuous exercise ,fever, high temperature ,cold, mental tension and some other factors, the kidney vasospasm or congestion,leads to glomerular filtration membrane permeability increased and large protein escape from the net. Normal pregnant woman' protein in urine can have a little increase, which is relevant to the position ,renal flow increase,and glomerular filtration rate increases. After the causes are removed ,the functional proteinuria will disappear.
Pathological proteinuria is persistent proteinuria resulted from damaged ....
protein in urine continued to occur as some systerm or visceral organ have disease. Generally speaking ,more 150 mg protien in urine per 24 hours.
General in the three kinds
1. Glomerular proteinuria
Because of some reasons, glomerular capillary wall is damaged(such as immune damage), which makes the load reduce or lose and result in increased glomerular permeability. So, after more plasma protein filter ,beyond the heavy absorption ability of the renal tubular and lead to proteinuria. Such as acute or chronic nephritis, lupus nephritis, diabetic nephropathy and other. Much more protein leak from glomeruli, amount of which beyond renal tubule's readsorption ability and finally proteinuria is formed.
2. Tubular proteinuria
when renal tubular becomes disease or renal tubular function faults , its heavy absorption ability decreases or secretion protien increases,lead to proteinuria. Such as renal tubular acidosis , kidney diseasa originate from analgesic, Antibiotic renal toxic performance etc
3、exudative proteinuria (dissolve proteinuria) patients' urine become murky when it heat to 40℃ ,freezing when it heat to 60℃, dissolution when it heat to 100℃. Tubular proteinuria is more common in myeloma, Primary amyloidosis, gigantic globulin hematic disease.
In case of pathological proteinuria, you must make treatment purpose clear and not eliminate protein blindly. We must remove the reason that cause proteinuria and achieve the purpose of treat disease fundamentally.

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