Types of IgA Nephropathy and Its Symptoms

IgA Nephropathy is a symptom complex of several nephropathies with the same immunopathological features. It has various clinical manifestations and pathological features, and can be classified into several clinical types.
In total, IgA Nephropathy can be divided into seven types in clinic:
I Type of Solitary Microscopic Hematuria: It is characterized with the solitary microscopic hematuria, and usually without the symptoms of proteinuria, high blood pressure, renal insufficiency and anemia. Patients with this type of IgA Nephropathy usually have a stable condition and it usually has a good prognosis.
II Type of Asymptomatically Abnormal Urinalysis Test: This type of IgA Nephropathy is the most commonly seen one. Its main clinical symptoms include microscopic hematuria, medium or small amount of proteinuria. As to most of the patients, this type of IgA Nephropathy have a good prognosis, while some cases may develop into Chronic Renal Failure, due to the little attachment with those symtoms.
III Type of Recurrent Gross Hematuria: This type of IgA Nephropathy is commonly seen among pupils and youth, which is likely induced by upper respiratory tract infection, overwork and so on. The urine of this type of patients presents with the change of colour, such as looking brown, like the water after washing meat, flavored tea, coca, soy sauce, etc. This type of IgA Nephropathy usually has a good prognosis as well.
IV Type of Vasculitis: Clinical hematuria is an obvious symptom of patients with this type of IgA Nephropathy. Besides, amenia and high creatinine are the features of this type when compared with others. Some severe patients may even present with Acute Renal Failure. This type of IgA Nephropathy usually has an acute onset, and if patients don’t receive effect treatment, the disease is quite easily to deteriorate, and even causes Chronic Renal Failure.
V Type of Massive Proteinuria: Male patients are more vulnerable to this type of IgA Nephropathy with the symptoms of massive proteinuria (>3.5g/24h), low plasma albumin (<35g/L) and hypercholesterolemia, besides, hypertension and renal insufficiency are also commonly seen among patients with this type of IgA Nephropathy.
VI Type of Hypertension: As to this type of patients, hypertension usually happens with the onset of disease or becomes the obvious symptom in course of the disease. Most patients of this type are males with an average onset age of 35. In clinic, these patients usually present with severe anemia and increased night urine. Moreover, this type of IgA Nephropathy is quite easily to induce renal insufficiency.
VII Type of Renal Failure in Advanced Stage: This type of IgA Nephropathy is the end stage of those six types above. Patients with this type of disease usually have a serum creatinine more than 5mg/dl.

As we can find above, although some types of IgA Nephropathy have mild symptoms and good prognosis, if the patients don’t receive effective treatment in time, IgA Nephropathy will finally arouse Renal Failure, and in that moment, the damage of kidney will not be reversed at all, so patients with IgA Nephropathy need to adopt treatment aggressively, and strive to recover as soon as possible.