Comprehensive Introduction about Serum Creatinine

What is serum creatinine?
Creatinine level,is One of the main methods to know of the function of the kidney. How dose creatinine work? Endogenous creatinine is the product of Muscle metabolism in our body. Creatine change into creatinine slowly mainly through irreversible enzyme reaction dehydration in the muscle and released into blood ,with the urine. So, serum creatinine has a close relationship with the total muscle in the body and it hardly influenced by diet. As a kind of small molecule, creatinine is filtered through glomerulus and little of it is absorbed by kidney tubules. Thus the daily creatinine produced in the body are almost discharged with urine and generally speaking it not affected by the amount of urine. Creatinine accumulates into the toxin in the body if the kidney function insufficiency. The normal higher limit of plasma creatinine is 100 micromole per liter and different hospital has different testing standard. But it always would not over 120 micromole per liter .Creatinine clearance rate (Ccr) is endogenous creatinine in some milliliter blood plasma is cleaned out within a unit time in kidney.Endogenous creatinine clearance test can reflect the function of glomerular filtration and can rough estimate the number of the effective kidney unit.Then it is quantitative test about determination renal damage.It is one of the preferable clinical kidney function tests for its simple operation method,less interference factors and high sensitivity.

What can cause high serum creatinine?
The density change of serum creatinine is mainly decided by the glomerular filtration ability(glomerular filtration rate).The density of serum creatinine increases if the filtering function decreases. If the serum creatinine is higner than the normal rate, that most means the kidney is damaged,because the serum creatinine can more accurately reflects the damage of the kidney but it is not the sensitive index. The serum creatinine could increased obviously as the glomerulus filtering rate decrease to one third level of the normal person. In other words ,while the damage of the kidney is lighter milder,people would not have a strong feeling as body has a strong metabolic ability.Then when many people feel sick,vomiting and dizzy,the damage of the kidney is seriously and the serum creatinine beigins to increase obviously.

The harms of high serum creatinine
1、Sodium metabolism disorders:high creatinine leads to Hyponatremia or hypernatremia.
2、Potassium metabolism disorders:　high creatinine offen appear with hyperkalemia or hypokalemia .
3、Water metabolism disorders:include diuresis, nocturia increased, thirsty, dry mucous membrane, lack of energy and so on;or systemic oedema、increases in blood pressure、pulmonary oedema and Heart failure etc.
4、Aluminum, magnesium and copper, zinc, selenium metabolic abnormalities, etc. 5、renal osteopathy:bone pain and proximal muscle weakness;bone pain often for systemic,，the following bust pragmatic bone is more serious,skeleton abnormal leads to short stature and other symptoms.
6、metabolic acidosis：creatinine high patients offen breathe deep and long 、loss of appetite 、abdominal pain 、nauseat、vomite、weak、headache、the restless even coma and other symptoms
7、circulation system lesions
8、digestive system lesions.
9、blood system lesions，such as blood nephropathy anemia,and so on.
10、respiratory system disease.