2012年10月15日星期一

What are the causes of proteinuria in kidney disease


Do you know what are the causes of proteinuria in kidney disease?
1 Due to the increased glomerular permeability, the filtration of normal plasma protein is increase and the protein has beyond the heavy absorption ability of the kidney tubules.(MAU nephritic syndrome)
2 The function defect of the kidney tubules disturbs the heavy absorption ability of the tubules to the normal protein from glomeruli.
3 More IGA to be produced comes from the urinary tract infections.
4 The activity of Adrenaline and Angiotensin is increase when the body in a state of stress. This leads to arteriola glomerularis afferens and arteriola glomerularis efferens contracted. Arteriola glomerularis afferens contracted makes plasma albumin and other macromaolecule protein easily pass the GBM. If arteriola glomerularis efferens contracted more than arteriola glomerularis afferens, the capillary hydrostatic pressure and filtration fraction of glomerulus is increase. So the plasma protein is more easily through the GBM. All these cause functional proteinuria, and do not mean the damage of glomerulus and kidney tubules.
All the proteinuria patients may have one or some causes to produce protienuria. PSGN patients may have changes of the permeability of the glomerular and inflammation of renal tubular. The classification of proteinuria is based on these physiopathologic mechanisms .

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