How does Henoch-Schonlein Purpura Nephritis Cause Kidney Failure

Henoch-Schonlein Purpura Nephritis Causes Kidney Failure if left uncontrolled. This article mainly explain how Henoch-Schonlein Purpura Nephritis Causes Kidney Failure and knowing about this is helpful for us to choose treatment.
Diagnosis of Henoch-Schonlein Purpura Nephritis is based on mesangial proliferation of glomeruli. With Henoch-Schonlein Purpura Nephritis, IgA and some immune complexes can be detected in mesangial area. IgA and immune complexes release inflammatory factor which stimulate our kidney and thus causes inflammatory reaction.
Inflammatory reaction is a kind of self-protective reaction, through which, inflammatory reaction can be removed effectively. However, if our immune system is abnormal, inflammatory reaction will last and becomes more and more intense. Usually, when immoderate inflammatory reaction causes damage our own renal functional cells, which impair our kidney function. Usually, when kidney damages are caused by Henoch-Schonlein Purpura, Henoch-Schonlein Purpura Nephritis appears. With no effective treatment, more and more renal functional cells, kidney functions becomes poorer and poorer and finally, kidney failure appears.
Kidney failure is the end consequence of Henoch-Schonlein Purpura Nephritis and it appears when kidneys are totally failed. However, not everyone with Henoch-Schonlein Purpura will certainly suffer from Henoch-Schonlein Purpura Nephritis. For Henoch-Schonlein Purpura patients, if they get their disease controlled timely and effectively, kidney damages can be avoided and obviously, kidney failure can be avoided.
When Henoch-Schonlein Purpura Nephritis is diagnosed, many patients adopt hormone medications as their treatment. However, hormone medications only help to remove symptoms, and they can not remove IgA and immune complexes. Immune complexes are the root causes of kidney damages, so as long as them exist in kidney, new kidney damages will be caused and Henoch-Schonlein Purpura patients eventually run to kidney failure.
At present, only Immunotherapy is effective in removing immune complexes and IgA. Through this treatment, Henoch-Schonlein Purpura patients can be brought under control effectively and consequently, Henoch-Schonlein Purpura Nephritis stop developing to kidney failure.