New Treatments for IgA Nephropathy

IgA Nephropathy is a common kidney disease and it is an autoimmune kidney disorders which is characterized by the deposition of IgA as well as other immune complexes in the glomerular mesangial areas. The main clinical manifestation is hematuria with or without proteinuria. In serious cases, it is easy to cause severe hypertension or renal insufficiency it not effective treatments are received timely and in the end the disease will gradually develop into renal failure.
The kidneys are vital organs to human beings and it can help maintain the balances in the internal environment and in case of IgA nephropathy, the kidney can not function normally and there will be excessive accumulation of immune complexes and metabolic wastes in the body and patients will have a series of symptoms and signs and their life quality will be greatly affected.
Conventional therapies for IgA nephropathy are mainly to use hormones and cytotoxic drugs to suppress the abnormal immune inflammations. However this is just symptomatic treatment which only aims at alleviating the symptoms without any repairing of the kidney damages, therefore the disease is easy to relapse under some inducements such as cold, fever or infections. What is worse, long term intake of hormones and immunosuppressive will cause a lot of side effects and complications to the patients.
Since the root cause of IgA nephropathy is the dysfunction of the immune system which cause the deposition of IgA and other immune complexes in the kidneys and cause a series of symptoms, the key point in treating IgA is to regulate the disorders in the kidneys and eliminating IgA and other immune complexes out of the body. In this regard, the latest therapy---immunotherapy has particularly good curative effects on IgA nephropathy.
Immunotherapy consists of six steps include immune diagnosis, immune clearance, immune blockage, immune tolerance, immune regulation and immune protections. The mechanism of immunotherapy is to eliminating the immune complexes and other metabolic wastes out of the body by dilating blood vessels and speeding up blood circulation. Then the damaged kidneys will be repair and the after the therapy the kidney functions will be recovered and the immunity will be enhanced.
Keywords: IgA nephropathy, treatments, immunotherapy