What causes Lupus Nephritis

Lupus Nephritis is an inflammation of the kidney caused by systemic lupus erythematosus (SLE), a disease of the immune system. In the following content, we will see what causes the Lupus Nephritis, hope the information could help you.
The root cause of Lupus Nephritis is the immune system disorder. When the immune system of patients with lupus becomes abnormal, the B lymphocyte will have the excessive activation, then the virulent Anti-DNA antibody will be produced. These anti-DNA antibody will first combine with the DNA, nucleosome, histone in the blood and then produce the immune complexes. These immune complexes will flow through every corner of the body with the blood. Because the kidneys have the special substance which can attract some immune complexes to deposit in the kidneys.
When the immune complexes deposit in kidneys, kidneys will treat them as the foreign body, so the huam body will release some inflammatory mediators to take part in the immune inflammation reaction whose purpose is to eliminate these immune complexes. However, the immune inflammation will also damage the kidneys, so kidney damage happens. Then lots of symptoms appear. With the kidney damage becomes worse and worse, less and less kidney function will be left, finally, the Lupus Nephritis develops into kidney failure or uremia.
From the above information, we know that the treatment patients with Lupus Nephritis need is the one that can eliminate the immune complexes both in the blood and in the kidneys, and stop the immune inflammation reaction and repair the damaged kidneys.