2012年12月21日星期五
Kidney Disease That May Reoccur after Kidney Transplant
Kidney transplant is always adopted as the last option for people with totally failed kidneys. Kidney transplant is a medical procedure in which a healthy kidney is put into patient’s body to relapse the failed kidney to work. Kidney transplant plays an important role in medical filed for kidney failure patients. However, not every patient will live a normal life after kidney transplant. In many cases, kidney disease reoccur after the transplantations. Now, let’s have a look about the list of disease which recur following renal transplant.
1. Primary FSGS: FSGS is the abbreviation of Focal Segmental Glomerulosclerosis and according to clinical studies, about 40% of cases will recur, many of which ultimately lead to allograft failure. Plasma exchange and aggressive immunosuppression maybe of value.
2. Primary membranous nephropathy: the reoccurrence rate of it is 30%. Also, the novo membranous nephropathy occurs in 1-2% of all transplant.
3. MPGN: Mesangial Proliferative Glomerular Nephritis (MPGN) can be divided into different types and the reoccurrence of type 2 MPGN is as high as 90%, whereas type 1 MPGN has a recurrence rate of only about 25%.
4.HUS: the D+ type of HUS typically does not recur post-transplant; however, the congenital forms of HUS (e.g. mutations in factor H, grouped amongst the D-type of HUS) recurs frequently
5. IgA Nephropathy: IgA Nephropathy is also an autoimmune disease with reoccurrence rate 50% after renal transplantation. But this disease seldom cause allograft dysfunction.
6. Henoch-Schonlein Purpura: ki7. diabetic nephropathy: like IgA Nephropathy, pathologic hallmarks of diabetic nephropathy are commonly observed post-trasnsplant, but this damage typically takes years, if not decades, to become clinically significant. dney problem caused by 7.Henoch-Schonlein Purpura is commonly called Purpura Nephritis which as reoccurrence rate of 50% after kidney transplant. Similar with IgA Nephropathy, purpura nephritis cause seldom cause allograft dysfunction.
8. primary hyperoxaluria: this disease occurs essentially 100% of the time unless it is performed as a dual liver-kidney transplant.
There are probably others, but these are some of the major ones to remember.
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