Diabetic nephropathy causes and prevention

Diabetes is a common chronic disease, can cause a lot of complications, diabetic nephropathy is a common complication of harm is very large. Then the cause of diabetic nephropathy, what does? How do we prevent diabetic nephropathy? Here I will introduce three tips preventing diabetic nephropathy.
Cause of diabetic nephropathy
1, high blood pressure. Hypertension and diabetic nephropathy has no direct relationship, but to the course of pre-existing hypertension or microalbuminuria period after blood pressure can accelerate the deterioration of renal function and progression of diabetic nephropathy, increased urinary excretion of albumin.
2, high blood sugar. Diabetic nephropathy and high blood sugar closely related to poor glycemic control can accelerate the development of diabetic nephropathy, good blood glucose control can significantly slow down its development. After hyperglycemia and glycation endproducts cause an increase in mesangial cell proliferation, extracellular matrix increased, mesangial expansion, glomerular basement membrane thickening.

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3, renal blood flow abnormalities. High blood sugar, high glomerular perfusion, high filtration state, increased pressure across the capillary wall, the expansion of mesangial cells, epithelial cell foot process fusion and produce dense droplets in glomerular epithelial cells detached from the basement membrane ʱ?? Glomerular basement membrane collagen Ⅳ messenger ribonucleic acid increased, the basement membrane thickening, and ultimately the formation of diffuse mesangial nodular lesions occur glomerulosclerosis. In the case of increased pressure, protein filtration increase, also deposited in the mesangial area and glomerular basement membrane, promoting stromal proliferation, creating a vicious cycle, and may result in nodular and diffuse glomerulosclerosis.
Three Tips for preventing diabetic nephropathy
First, control blood sugar, and more concerned about their kidney health, early detection and early treatment of kidney complications, thereby delaying the progression of diabetic nephropathy. "Sugar" Friends to remember three standards: In accordance with the Chinese Medical Association Diabetes Society "China Type 2 Diabetes Guide (2013 edition)" in the integrated control target, fasting blood sugar is not more than 7.0 mmol / l, postprandial blood sugar is not more than 10.0 mmol / l, glycosylated hemoglobin does not exceed 7%.
Second, regular checks of blood pressure, urine, urine albumin, serum creatinine (for calculating GFR creatinine to assess kidney function), etc., for early detection of chronic kidney disease.
Third, select good renal safety of oral hypoglycemic agents. The most common and most sulfonylurea and other biguanide oral hypoglycemic agents, mainly excreted by the kidneys, drug accumulation may occur when renal insufficiency, an increase in side effects and may aggravate renal damage. Therefore, the "renal insufficiency" is the wide variety of oral hypoglycemic agents contraindications, such patients may face without oral hypoglycemic agents available.

Cause of diabetic nephropathy, what does? How to prevent diabetic nephropathy it? Above in detail for everyone to do a presentation, I hope my friends do routine preventive, to avoid diabetic nephropathy.